INTRAUTERINE THERAPY

MEDICATION DOSAGE, ROUTE, FREQUENCY INDICATIONS
Acetylcysteine solution (20%) (200 mg/ml) 30 mls (6 grams) diluted into 150 mls sterile saline infused into uterus Mucolytic; management of chronic uterine inflammation
Amikacin sulfate (250 mg/ml) 1 to 2 grams; buffer with 10 mls sodium bicarbonate (8.4 %) then qs to 50 mls with sterile saline Antibiotic (Gram-negative spectrum)
Amphoteracin B (50 mg/vial) 100 to 200 mg reconstituted in 50 mls sterile saline Antifungal agent
Ampicillin (1 gm vial) 1 to 2 grams, reconstitute in 50 mls sterile saline Antibiotic (Gram-positive spectrum primarily)
Ceftiofur (Naxcel®) (1 gm vial) 1 gram, reconstitute with 20 mls sterile water Antibiotic (broad spectrum)
Ciprofloxacin (10 mg/ml) 400 to 500 mg, reconstitute to 50 mls with sterile saline Antibiotic (primarily Gram-negative spectrum); should reserve for use against organisms resistant to other antibiotics
Clotrimazole (100 mg/tablet)* 500 to 700 mg in 50 mls sterile saline Anti-fungal agent
Fluconazole (200 mg/tablet)* 100 to 250 mg in 50 mls sterile water; to reconstitute, add 5 mls DMSO to 1 gram (5 tablets) of fluconazole to dissolve; divide into 4 aliquots of 250 mg each; qs to 50 mls with sterile water Antifungal agent
Gentamicin (100 mg/ml) 1 to 2 grams; buffer with 10 mls of 8.4 % sodium bicarbonate; qs to 50 mls sterile saline Antibiotic (Gram-negative spectrum)
Kerosene (K-1) 250 to 500 mls; uterine infusion Chemical curettage of the uterus; used in mares with chronic mucus production; infuse into uterus with disposable tubing; lavage uterus the next day and daily for 1 to 3 days thereafter as needed
Lufenuron (Program®) (270 mg/packet)* 540 mg in uterus suspended in 50 mls sterile saline, 270 mg applied to vaginal vault and clitoral area Treatment of fungal endometritis (specifically for yeast organisms with chitin in cell wall)
Miconazole (Monistat® 1 or equivalent) (1,200 mg insert) 1,200 mg insert deposited into uterus Antifungal agent
Nystatin (100,000 USP units/gram; 30 gram vial)* 5 grams suspended in 50 mls sterile water; or 0.5 million units Antifungal agent
Penicillin (Potassium) (5 or 20 million units/vial) 5 million units; reconstitute in 50 mls sterile saline Antibiotic (Gram-positive spectrum)
Penicillin (Procaine) (300,000 units per ml) 15 mls; dilute to 50 mls in sterile saline Antibiotic (Gram-positive spectrum)
Ticarcillin/Clavulanic acid (Timentin®) (3.1 gm per vial) 3.1 grams; reconstitute to 50 mls with sterile saline Antibiotic combination; clavulanate blocks penicillinase; used for Gram-positive organisms and Pseudomonas aeruginosa

*medication reported to be used at other facilities; not in use at CSU

© 2024 COLORADO STATE UNIVERSITY
All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form or for any means, including printing, copying, photocopying, or utilized by any information strorage or retrieval system without written permission from the copyright owner.
Version 3.0.0.0
Equine Reproduction Laboratory. erl.colostate.edu