UTERINE LAVAGE

MEDICATION DOSAGE, ROUTE, FREQUENCY INDICATIONS
Ceragyn™ 60 ml; uterine infusion Anti-microbial peptide mimic; treatment of infectious endometritis; reduction of biofilm
Dimethyl sulfoxide (DMSO) (99%) 50 to 200 ml DMSO per liter saline; may repeat as needed; follow with lavage with 1 liter saline or LRS Anti-inflammatory; uterine lavage to decrease mucus production; also effective in reducing biofilm
Hydrogen Peroxide (3%) 60 to 120 mls infused into uterus; follow the next day with lavage using sterile saline or lactated Ringer’s solution (LRS) Treatment of fungal endometritis
Lactated Ringer’s Solution (LRS) or Normosol-R or Hartmann's Solution 1 to 4+ liters; repeat lavage until effluent fluid is clear Uterine lavage (Note: neutral pH)
Povidone-Iodine (Betadine® Solution) (10%) 10 to 15 mls added to 1 liter sterile saline Treatment of bacterial or fungal endometritis; may also add povidone-iodine to tap water for uterine lavage of postpartum mare, mare with retained placenta, or mare with a pyometra
Saline (0.9%) 1 to 4+ liters; repeat lavage until effluent fluid is clear Uterine lavage (Note: acidic pH)
Tris-EDTA and Tricide® 250 to 500 mls infused into uterus; then lavage uterus with lactated Ringer’s solution (LRS) Chelator of heavy metals; used as uterine infusion prior to antimicrobial therapy to reduce chelation and subsequent inactivation of antimicrobial agents; reduction of biofilm
Vinegar (Distilled White) (2%) 20 to 100 mls added to 1 liter sterile saline Treatment of fungal endometritis

*medication reported to be used at other facilities; not in use at CSU

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Equine Reproduction Laboratory. erl.colostate.edu